ATLAGRA (Sildenafil Citrate)
is a medicine used in the treatment
of erectile dysfunction (ED). It
helps men with ED achieve and
maintain harder erections within 30
minutes and lasting up to 4 hours.
An erection is produced via a
complex chain of events, involving
signals from the nervous system and
the release of chemical messengers
within the tissues of the penis. One
of these chemical messengers is
called cyclic guanosine
monophosphate (cGMP). Cyclic GMP
causes the blood vessels in the
penis to widen by relaxing a thin
layer of muscle found in the blood
vessel walls. This allows more blood
to enter the penis, which ultimately
results in the penis becoming rigid
and erect. Cyclic GMP is normally
broken down by a chemical called
phosphodiesterase type 5 (PDE5). The
citrate salt of sildenafil is a PDE5
inhibitor, thus preventing the
action of PDE5 and stopping the
breakdown of cyclic GMP. This causes
the blood vessels to remain dilated
for longer, thus improving blood
flow to the penis and maintaining an
erection.
As sildenafil enhances the actions
of the chemical messengers
responsible for producing an
erection, it will only work once
these messengers are present. Sexual
stimulation is still required for it
to produce and maintain an erection.
The dose should be taken
approximately one hour before
intended sexual activity.
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